SGT-151: Advanced Research Opportunities and Insights
In the evolving field of synthetic cannabinoid research, compounds like SGT-151 continue to attract significant interest from scientific communities studying cannabinoid receptor interactions, pharmacology, and novel psychoactive substances (NPS). Also known as CUMYL-PEGACLONE, this gamma-carboline-based synthetic cannabinoid represents a unique structural class that has been investigated for its potential in understanding endocannabinoid system dynamics and receptor binding profiles.
What is SGT-151 (CUMYL-PEGACLONE)?
SGT-151, chemically identified as 5-pentyl-2-(2-phenylpropan-2-yl)pyrido[4,3-b]indol-1-one (CAS: 2160555-55-3), is a designer synthetic cannabinoid first identified in herbal blends and research contexts around 2016. Unlike traditional indole-based synthetic cannabinoids, SGT-151 features a distinctive gamma-carboline core, which differentiates it structurally and pharmacologically from earlier generations like JWH or AM series compounds.
This structural innovation contributes to its high potency as a CB1 receptor agonist, making it a valuable tool for in vitro and in vivo studies exploring cannabinoid receptor activation, signal transduction pathways, and potential therapeutic or toxicological implications. Researchers often acquire SGT-151 as a high-purity reference material for analytical, pharmacological, and forensic applications.
Key characteristics include:
- High binding affinity to cannabinoid receptors, often leading to full agonism.
- Metabolite profiles (e.g., hydroxylated and dealkylated forms) that are studied for detection in biological samples.
- Availability in controlled, high-purity forms suitable for laboratory use.
Advanced Research Opportunities with SGT-151
The unique profile of SGT-151 opens several promising avenues in scientific research:
- Pharmacological Profiling — Studies on receptor affinity, efficacy, and selectivity help map differences between synthetic cannabinoids and natural cannabinoids like THC, aiding in the development of selective agonists or antagonists.
- Metabolite Identification and Detection — Research into SGT-151 metabolites supports advancements in forensic toxicology, drug screening methods (e.g., LC-MS/MS), and understanding metabolic pathways in human liver models.
- Structure-Activity Relationship (SAR) Studies — The gamma-carboline scaffold provides a platform to explore how modifications (e.g., fluorination in analogs like 5F-SGT-151) influence potency, toxicity, and receptor interactions.
- Toxicological Evaluations — Investigations into acute and chronic effects contribute to broader knowledge of NPS risks, including potential for adverse reactions, which informs regulatory and public health strategies.
- Analytical Standard Development — High-purity SGT-151 serves as a certified reference material for calibration in labs monitoring emerging designer drugs in seized samples or biological matrices.
While SGT-151 has been associated with recreational use in some contexts and is subject to varying international controls (e.g., proposed Schedule I placement in certain jurisdictions), its primary value lies in controlled scientific environments where it advances understanding of cannabinoid pharmacology.
SGT-151 Supply for Research: Insights from Universal Chemical Trading GmbH
For researchers requiring reliable, high-quality sources of SGT-151, Universal Chemical Trading GmbH (UCTR GmbH) positions itself as a leading manufacturer and supplier of this compound. Based in Germany, UCTR GmbH specializes in producing and distributing high-purity chemicals for industrial, scientific, and research applications.
As one of the largest manufacturers of SGT-151 for sale, the company emphasizes stringent quality controls, bulk production capabilities, and compliance with standards for handling research chemicals. Their expertise in chemical manufacturing ensures consistent purity levels essential for reproducible experimental results.
UCTR GmbH’s broader portfolio includes specialized reagents for various sectors, but their production of SGT-151 caters specifically to laboratories and institutions conducting advanced cannabinoid research. Researchers can contact the team for technical specifications, purity certifications, and supply options tailored to research needs.
Conclusion: Unlocking Potential in Synthetic Cannabinoid Research
SGT-151 (CUMYL-PEGACLONE) remains a compelling subject for advanced studies in cannabinoid science, offering insights into receptor pharmacology, metabolism, and novel compound design. With ongoing research highlighting its unique properties, access to high-purity material from trusted manufacturers is crucial for progressing the field responsibly.
For institutions and researchers seeking premium SGT-151 for laboratory use, explore offerings from Universal Chemical Trading GmbH at https://uctr-gmbh.de/. Reach out to their experts at info@uctr-gmbh.de for detailed product information, data sheets, and inquiries about research-grade supplies.
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